Chronic obstructive pulmonary disease (COPD) is a chronic, progressive respiratory\ndisease and the third leading cause of respiratory disease mortality.\nThe diagnosis of COPD is changed to acute exacerbation of COPD (AECOPD)\nwhen respiratory symptoms become worse, beyond normal day-to-day variations\nand severely enough that changes in medication are required. Both neutrophils\nto lymphocyte ratio (NLR) and peripheral blood eosinophilia (PBE)\nare rapid and relatively inexpensive tests that can be easily applied in the\nclinical practice for the diagnosis and treatment of AECOPD patients. Furthermore,\ncurrent studies found that NLR and PBE had a higher accuracy rate\nthan other traditional markers (Leukocyte count and C-reactive protein) for\nthe diagnosis and management of AECOPD. Besides, recent studies determined\nthat NLR and PBE can be used for prediction of future exacerbations\nin COPD patients. This review aims to explore the current knowledge about\nthe significance of NLR and PBE in AECOPD patients.
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